Endocrine Abstracts

Background: We report this interesting case of worsening diabetes and diabetes ketoacidosis in a young male with acromegaly who was commenced on Pasireotide treatment.Case Report: This 30 years gentleman was diagnosed with Acromegaly in April 2015. He underwent trans- sphenoidal surgery in January 2016 with significant residual tumour post-surgery. His IGF1 remained elevated and was unresponsive to Lanreotide. He was commenced on adjuvant therapy with Pa...

Objective: Evidence shows type 1 diabetes leads to vascular damage and neuropathy. The purpose of this study was to perform a systematic review and a meta-analysis to asses the evidence of the effects of type 1 diabetes on hearing function.Methods: Three different electronic databases were used to identify eligible studies including a manual searching of references. The articles obtained were independently reviewed by two authors using predefined inclusi...

Background: Graves’ disease with ocular myasthenia are autoimmune disorders with their association being rare but well documented. There is overlap of ocular clinical features in both these conditions which can pose a significant clinical challenge. The diagnosis is necessary for both therapeutic and prognostic reasons.Case presentation: A 35 year old lady presented with diplopia on downward gaze for 4 weeks. There is history of unintentional weight...

Older population and people with type II diabetes have a significantly higher rate of decline in cognitive function. However, the mechanisms are poorly understood. There are strong links between insulin and cognitive function supported by epidemiological data from humans and animal studies and in vitro research. Protein kinase C (PKC) signaling cascades and insulin pathways are closely integrated. The consequences of PKC activation by insulin in the CNS influence memory...

Introduction: Graves’ disease is an autoimmune disorder of the thyroid gland causing over-production of thyroid hormone. Although this disorder can lead to systemic changes throughout the body, the most common extrathyroid manifestation of Graves’ disease is ophthalmopathy. Patients can have significant ocular prominence from the increase in intraconal and extraconal fat and muscular hypertrophy. This can lead to vision changes, decreased ocular motilit...

Paraneoplastic Cushing's syndrome is a rare disease and is usually associated with small lung cancer or bronchial carcinoid tumour. In this case report we present an unusual case of metastatic neuroendocrine tumour of the pancreas presenting with florid Cushing's syndrome. A 45-year-old female presented with four-month history of worsening blurred vision, dry mouth and lethargy. In the hindsight, for the past three ...

Introduction: Graves’ disease is an autoimmune disorder of the thyroid gland causing over-production of thyroid hormone. Although this disorder can lead to systemic changes throughout the body, the most common extrathyroid manifestation of Graves’ disease is ophthalmopathy. Patients can have significant ocular prominence from the increase in intraconal and extraconal fat and muscular hypertrophy. This can lead to vision changes, decreased ocular motilit...

Paraneoplastic Cushing's syndrome is a rare disease and is usually associated with small lung cancer or bronchial carcinoid tumour. In this case report we present an unusual case of metastatic neuroendocrine tumour of the pancreas presenting with florid Cushing's syndrome. A 45-year-old female presented with four-month history of worsening blurred vision, dry mouth and lethargy. In the hindsight, for the past three ...

Introduction: The pandemic resulted in changes in delivery of healthcare. Most children and young people (CYP) present with symptoms of T1D for the first time to primary care. Delayed diagnosis is common and associated with risk of life-threatening diabetic ketoacidosis (DKA). In Cardiff, we had a pre-pandemic QI project to improve early diagnosis of T1D. We escalated responses, introduced initiatives to facilitate early diagnosis.Aim: To develop effecti...

Background: A growing number of people in the United Kingdom are seeking medical treatment to align their sexual characteristics with their gender identity. With waiting lists for specialist clinics currently lasting over four years, endocrinologists are increasingly called upon to manage transgender care as part of their general duties. While surveys and qualitative studies from North America have investigated doctors’ ideas and experiences of transgender care, little is...